What Is the Investigational Study Drug and Device?

The investigational study drug is called VGX-3100. It is delivered with a medical device that is designed to increase the amount of study drug or placebo taken up by the muscle. Doctors hope that VGX-3100 delivered by the medical device will boost your body’s immune response to human papillomavirus (HPV) infection and clear the precancerous cells of the cervix.

How does the investigational study drug work?

VGX-3100 may boost your immune system.

• VGX-3100 is injected by inserting the needle from the study device into the muscle of your upper arm (deltoid) or thigh (rarely). This investigational drug and device combination treatment will last about 7 seconds
• Once inserted, VGX-3100 can show the body how to make proteins that can boost the body’s immune response to HPV infection

These new proteins may become “targets” for the body’s immune system. These targets may help the immune system find and treat the precancerous cells of the cervix.

How is the placebo given?

The placebo is given in the same way as the investigational study drug. There is a 1 in 3 chance you will be in the placebo group. If you are in the placebo group, you may not receive any benefits from this study.